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Request for Applications: Pediatric Networks for the Human Cell Atlas
The Chan Zuckerberg Initiative invites applications for three-year collaborative projects for the generation of healthy, single-cell reference data from pediatric tissue samples for the Human Cell Atlas (HCA).
The Human Cell Atlas (HCA) is a global effort to create a reference map of all cell types in the healthy human body in order to generate a fundamental reference for biomedical research and improve our understanding of health and disease. With advances in single-cell biology technology and growing interest from the international community, this scientific grassroots project has progressed from conceivable to feasible. Progress over the past several years has resulted in remarkable advancement toward first drafts of many adult organs and tissues. However, similar reference data for pediatric tissues is less commonly represented in emerging tissue atlases. Yet this data is critically important for clarifying cellular maturation through childhood while building a foundation for understanding disease progression and therapeutic strategies in children.
This Request for Applications (RFA) welcomes proposals that will make significant contributions toward single-cell reference data for the community of patients, clinicians, and researchers engaged in pediatric research. This opportunity is intended to support active collaborative teams of researchers that have access to established resources and protocols that are ready to be extended and scaled. The opportunity is also intended to support new collaborative teams that will benefit from the experience of existing teams while bringing complementary and differentiated perspectives and resources. The opportunity aims to support a variety of collaborative teams that will all make contributions to the larger community via regular engagement and sharing of learnings, data, samples, and other resources.
Teams should consist of at least three principal investigators (PIs), including at least one computational biologist or data scientist, one pediatrician actively engaged in clinical care, and at least one expert in single-cell biology. Community-engaged researchers should be involved in the collaboration and can come from domains including medicine, public health, fundamental research, or others that will ensure that the research is attuned to the needs of and connected with the participating communities providing pediatric tissue samples. The engagement researchers are incorporated into this opportunity to help provide, promote, and build culturally competent connections with the research participants and members of their community in such a manner that they are empowered to participate in Pediatric Networks research and also benefit from potential findings. This RFA is intended to support established teams as well as new collaborations. It is anticipated that successful applications will include teams that vary in size from small (three to four PIs on the team) to midsized (five to 10 PIs on the team) working together to make progress toward reference maps of healthy pediatric tissues.
Deadline: March 30, 2021
- This opportunity is focused on better understanding early life, including periods of infancy, juvenile, and early adolescent ages. Applications examining prenatal and fetal development are not eligible for this opportunity, nor are applications proposing sampling of adult tissues (greater than 18 years of age).
- Applications may be submitted by domestic and foreign nonprofit organizations, public and private institutions, such as colleges, universities, hospitals, laboratories, units of state and local government, and eligible agencies of the federal government. For-profit organizations are not eligible to apply. All grants will be awarded to institutions, not individuals.
- Organizations may be based in any country.
- There may be more than one application submitted by each organization.
- Each application should designate one Principal Investigator (PI) as the Coordinating Principal Investigator (Coordinating PI). The Coordinating PI will act as the administrative contact between CZI and all PIs on the grant (Co-PIs). The Coordinating PI must submit the application on behalf of all PIs. The Coordinating PI must be affiliated with the institution submitting the application, and grant funds will be awarded to that institution, which will take responsibility for distributing funds to any other institutions. Note that institutions outside the U.S. may not subcontract to U.S. institutions, so please be mindful when selecting the Coordinating PI/institution.
- Each application must have a minimum of three PIs (one Coordinating PI and two Co-PIs), but may designate up to 10 total PIs (one Coordinating PI and up to nine Co-PIs). If your application proposes more than 10 PIs, please contact firstname.lastname@example.org to explain and discuss how to submit the application.
- Principal Investigators may only serve as Coordinating Principal Investigator on one application.
- Principal Investigators may apply to join multiple Pediatric Networks applications, but will only be funded in a single final team. Should teams with overlapping PIs be selected as finalists, the teams will be asked to revise the members of their team such that each PI is only funded as a Coordinating PI or Co-PI on a single project. Collaboration and participation in multiple projects is allowed, but funding will be restricted to one project per PI.
Budget limits: Because varying projects require different resourcing levels, a budget limit has not been set on a per project basis. Proposed budgets should reflect the project scope. Indirect costs cannot exceed 15% of direct costs.