Request for Applications (RFA): HIV Cure-Related Research in Africa

Funding Agency:
CRDF Global

Most cure-related HIV research to date has focused on subtype B virus, which constitutes the majority of infections in North America, South America, Australia, and Western Europe, with the highest prevalence in cisgender men who have sex with men (MSM). However, subtype B represents only about 12% of the estimated 39 million people living with HIV globally. Subtype C virus constitutes the highest proportion of infections (47%), with the highest prevalence in cisgender women living in Sub-Saharan Africa. Almost 70% of all people living with HIV worldwide live in Sub-Saharan Africa and over 50% are cisgender women.  

Little is known about differences between subtype B HIV and other, more prevalent subtypes with respect to the biology of HIV persistence on ART, the frequency, and mechanisms of post-treatment control of HIV, and the response of non-subtype B viruses to curative strategies under development. Some evidence suggests that the frequency of viremic control in the absence of ART may be higher in females and in some populations in which non-subtype B virus is predominant. Additionally, one study of replication-competent persistent reservoirs in subtype C infection in Uganda demonstrated a smaller overall reservoir size as compared to individuals with subtype B virus in the U.S. More studies involving non-subtype B virus and people living with HIV in Africa are needed to better understand how these populations might respond to curative strategies currently under development for durable control of HIV in the absence of ART and/or reduction of persistent viral reservoirs.  

CRDF Global is soliciting research proposals that will expand our knowledge of HIV persistence and post-treatment control in people living with non-subtype B HIV in Africa. Proposals may propose basic, translational, preclinical, or clinical research studies using existing human samples or samples derived from separately funded HIV cohorts or clinical trials to analyze and compare non-subtype B HIV persistence and post-treatment control. 


This announcement invites application(s) from research institution located in Africa to submit research proposals that will (1) support HIV cure-related research in areas of Africa in which there is a high proportion of people living with HIV and (2), expand our understanding of the persistence of non-subtype B HIV in people on antiretroviral therapy (ART) and the mechanisms of post-treatment control of viremia following cessation of ART. 

Deadline: April 15, 2024

Agency Website

Eligibility Requirements

Research institutions located in Africa 



Funding Type





International Opportunities
Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

April 15, 2024