Research Centers for Cancer Systems Biology Consortium (U54)

Funding Agency:
National Institutes of Health

The National Cancer Institute (NCI) will fund a new Cancer Systems Biology Consortium (CSBC) that includes U54 CSBC Research Centers, a Coordinating Center (to be supported under companion U24 RFA-CA-15-015) and other related research projects supported through the U01 mechanism. The CSBC initiative aims to address challenges of complexity in basic and translational cancer research through the use of experimental biology combined with in silico modeling, multi-dimensional data analysis, and systems engineering.

This Funding Opportunity Announcement (FOA) invites U54 cooperative agreement applications for Research Centers that utilize systems biology approaches to build predictive models of cancer initiation, progression and metastasis. CSBC Research Centers will consist of interdisciplinary teams of scientists (e.g., engineers, chemists, computer scientists, mathematicians, physicists) and cancer researchers (e.g., cancer biologists, oncologists, pathologists) who collaborate to advance our understanding of cancer biology and oncology. CSBC Research Centers proposed in response to this FOA must demonstrate explicit integration of experimental biology and computational modeling to test and validate novel hypotheses or ideas of high importance in cancer research. In addition to the major research components, the Research Center will be required to develop an outreach effort in cancer systems biology aligned with the goals of the Research Center and the CSBC.


  • Letter of Intent Due Date(s): October 20, 2015; August 9, 2016; March 20, 2017
  • Application Due Date(s): November 20, 2015; September 9, 2016; April 20, 2017, by 5:00 PM local time of applicant organization.

​RFA-CA-15-014 Expiration Date April 21, 2017

Agency Website



Amount Description

Budget requests may not exceed $1.5M per year in direct costs.

Project period of 5 years is required

Funding Type





Engineering and Physical Sciences
Environmental & Life Sciences
Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

April 20, 2017