Research Projects in Cancer Systems Biology (U01 Clinical Trial Optional)

Funding Agency:
National Institutes of Health

 The National Cancer Institute’s (NCI) Cancer Systems Biology Consortium (CSBC) supports systems biology approaches to cancer research and includes U54 CSBC Research Centers, a U24 CSBC Coordinating Center and, through this FOA, well-defined, discrete and circumscribed U01 Research Projects. CSBC Research Projects are expected to involve interdisciplinary teams of scientists, engineers, and cancer researchers who collaborate to advance our understanding of the mechanisms underlying cancer initiation, progression, and treatment. CSBC Research Projects proposed in response to this Funding Opportunity Announcement must be based upon explicit integration of experimental biology and computational modeling to test and validate novel hypotheses in cancer research. 


  • Letter of Intent Due Date(s): 30 days prior to the application due date
  • Application Due Date(s): July 15, 2019, November 15, 2019, July 10, 2020, November 17, 2020, July 9, 2021, January 28, 2022

​PAR-19-287 Expiration Date New Date January 29, 2022 per issuance of NOT-CA-21-110 (was November 16, 2021)

Agency Website

Eligibility Requirements

 Due to the multi-disciplinary nature of the projects and the focus on collaboration and expertise sharing, this FOA encourages the use of the multi-PD/PI mechanism.



Amount Description

Application budgets are limited to $400,000 in direct cost per year and must reflect the actual needs of the proposed project.

 Project periods of up to 5 years may be proposed.  

    Funding Type





    Engineering and Physical Sciences
    Environmental & Life Sciences
    Medical - Basic Science
    Medical - Clinical Science
    Medical - Translational

    External Deadline

    January 28, 2022