Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01)

Funding Agency:
National Institutes of Health

The purpose of this Funding Opportunity Announcement (FOA) is to invite applications for projects to expand, improve, or transform the utility of mammalian cancer and tumor models for translational research.

With this FOA, the NCI intends to encourage submission of projects devoted to demonstrating that mammalian models or their derivatives used for translational research are robust representations of human biology, are appropriate to test questions of clinical importance, and provide reliable information for patients' benefit. These practical goals contrast with the goals of many mechanistic, NCI-supported R01 projects that employ mammals, or develop and use mammalian cancer models, transplantation tumor models, or models derived from mammalian or human tissues or cells for hypothesis-testing, non-clinical research. Among many other possible endeavors, applicants in response to this FOA could propose demonstrations of how to overcome translational deficiencies of mammalian oncology models, define new uses of mammalian models or their genetics for unexplored translational challenges, advance standard practices for use of translational models, test approaches to validate and credential models, or challenge current practices for how models are used translationally.

There is another related FOA that is suitable for R01 research projects whose goals relate to the goals of this FOA, but differ in scope - PAR-17-244, "Collaborative Research Projects to Enhance Applicability of Mammalian Models for Translational Research (Collaborative R01)".

R01 Due Date(s): Feb. 5, Jun. 5. Oct. 5

PAR-17-245 Expiration Date May 8, 2020

Agency Website



Amount Description

Application budgets are limited to $450,000 direct costs per year

The scope of the proposed project should determine the project period. The maximum project period is 5 years.

Funding Type





Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

October 5, 2019