Role of Environmental Stress in the Health Inequities of Alzheimer's Disease-Related Dementias (ADRD) (R01 - Clinical Trial Not Allowed)

This Notice of Funding Opportunity (NOFO) invites applications for basic, translational, and clinical research projects that propose to study the role of environmental stress on the health inequities in Alzheimer’s Disease Related Dementias (ADRD), including Frontotemporal Dementia (FTD), Lewy Body Dementia (LBD), Vascular Contributions to Cognitive Impairment and Dementia (VCID), and Mixed-Etiology Dementia (MED). Environmental stressors include but are not limited to heat, crowding, air pollution, noise, violence, and psychosocial stress. Many of these environmental stressors are more prevalent in rural and urban disadvantaged communities which also have a higher risk for ADRD. Thus, there is a need to identify environmental stressors that impact health inequities in ADRD and to determine the mechanistic underpinnings of this stress. This NOFO will support mechanistic, translational, and human subject studies to understand the relationship between environmental stressors and health inequities in ADRD. It is expected that these studies will identify environmental stressors related to health inequities in ADRD and their clinical relevance. Ultimately, these studies should accelerate research towards better therapeutic interventions and quality of life.

Deadlines:

• Letter of Intent Due Date(s): Thirty days prior to the due date. 

• Application Due Date: November 01, 2023

RFA-NS-24-024 Expiration Date November 02, 2023