This NOFO is intended to support research designed to identify the neurobiological, behavioral, psychosocial, and environmental mechanisms underlying the onset, trajectory, and outcome of schizophrenia and related psychotic disorders in mid- to late-life, with consideration for the identification of novel targets for future development of prevention and intervention efforts. Studies that leverage concepts, methods, and findings emerging from geroscience research on mechanisms of normative and pathological aging as predictors of risk, trajectory, and outcome of schizophrenia and related psychotic disorders in mid- to late-life are encouraged.
Research must target populations in the mid- to late-life age range or mid-late life stages, but relevant comparison populations may include those who are younger if scientifically justified.