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Screening system to identify SGLT1, GLUT5 inhibitors and activators
Glucose and fructose are carbohydrates and important sources of energy for the body. Glucose enters intestinal cells via the sodium glucose cotransporter protein 1 (SGLT1), while glucose transporter 5 (GLUT5) facilitates the absorption of fructose.
Modulating the absorption and uptake of different carbohydrates via these transport mechanisms are becoming increasingly relevant in managing various aspects of human health. Compounds interfering with these pathways have been identified in dietary ingredients. Similarly, drugs acting as inhibitors or activators of these transporters have also been developed.
We are seeking tools and screening capabilities to help understand the impact of different dietary ingredients on SGLT1 and GLUT5.
Deadline: Oct. 31, 2023