Shared Instrumentation Grant (SIG) Program (S10 Clinical Trial Not Allowed)

Funding Agency:
National Institutes of Health
The Shared Instrument Grant (SIG) Program encourages applications from groups of NIH-supported investigators to purchase or upgrade a single item of high-priced, specialized, commercially available instruments or integrated instrumentation system. The minimum award is $50,000. There is no maximum price limit for the instrument; however, the maximum award is $750,000. Instruments supported include, but are not limited to: X-ray diffractometers, mass spectrometers, nuclear magnetic resonance spectrometers, DNA and protein sequencers, biosensors, electron and light microscopes, flow cytometers, and biomedical imagers.


For this S10 opportunity, there is no limit on the number of applications an institution may submit. However, NIH will not accept duplicate or highly overlapping applications under review at the same time. For this reason, interested applicants can reach out to of OCRD as early as possible with the name of their instruments to minimize/prevent duplicate or overlapping applications being submitted.


  • Application Due Date: June 1, 2022; June 1, 2023; June 3, 2024

PAR-22-080 Expiration Date June 04, 2024

Agency Website

Eligibility Requirements

The PD/PI should document (in the biographical sketch) technical expertise directly related to the type of requested instrument. The PD/PI does not need to have an NIH research grant or any other research support but is expected to be an expert on the requested instrument. The PD/PI may be a core director, tenured, or non-tenured faculty member of the applicant organization. The PD/PI must be affiliated with the applicant organization and must be registered on eRA Commons.

Multiple PDs/PIs are not allowed under the S10 mechanism.

There is no restriction on the number of applications an institution (as identified by a specific UEI number) can submit to the SIG and/or High-End Instrumentation (HEI) Programs each year, provided the applications request different types of equipment. However, only one application to the Basic Instrumentation Grant (BIG) Program is allowed per receipt date. Concurrent SIG, HEI or BIG applications for the same instrument (or the same type of instrument with added special accessories – for example, to meet the HEI budget requirement) are not allowed unless documentation from a high-level institutional official is provided, stating that this is not an unintended duplication, but part of a campus-wide instrumentation plan. Applicants are advised to discuss with the SIG Scientific/Research Contact (Section VII) potential duplicates before submitting two applications for the same type of instrument.

A single application requesting more than one type of instrument (for example, a mass spectrometer and a confocal microscope) is not responsive to this FOA and will not be reviewed.



Amount Description

Applications will be accepted that request a single, commercially available instrument or an integrated instrumentation system. The minimum award is $50,000. There is no upper limit on the cost of the instrument, but the maximum award is $600,000. Since the cost of various instruments will vary, it is anticipated that the amount of the award will also vary. S10 awards do not allow indirect costs.

It is expected that applicants will employ the most economical approaches, including securing academic discounts, to formulate a cost-effective budget while meeting users' scientific needs.See Section IV. 6. Funding Restrictions Funding Restrictions for additional details.

Funding Type





Engineering and Physical Sciences
Environmental & Life Sciences
Medical - Basic Science
Medical - Clinical Science
Medical - Translational

Internal Nomination




External Deadline

June 3, 2024