Silvio O. Conte Centers for Basic Neuroscience or Translational Mental Health Research (P50 Clinical Trial Optional)

Funding Agency:
National Institutes of Health

This Funding Opportunity Announcement (FOA) encourages applications for Silvio O. Conte Centers for Basic Neuroscience or Translational Mental Health Research. The NIMH seeks teams of researchers working at different levels of analysis and employing integrative, novel, and creative experimental approaches to address high-risk, high-impact questions with the primary objectives of: (a) advancing the state of the science in basic brain and behavior research that will uncover and dissect the underlying mechanisms that will ultimately provide the foundation for understanding mental disorders; (b) supporting the integration and translation of basic and clinical neuroscience research on severe mental illnesses; and/or (c) advancing our understanding of the neurobehavioral developmental mechanisms and trajectories of psychopathology that begin in childhood and adolescence. The Conte Centers program is intended to support interdisciplinary basic neuroscience or translational research that demonstrates an extraordinary level of synergy, integration, and potential for advancing the state of the field. This program is intended only for projects that could not be achieved using other, more standard grant mechanisms.  


  • Letter of Intent Deadlines: 30 days prior to the application due date
  • Application Deadlines: June 7, 2023; June 7, 2024; June 9, 2025

PAR-22-155 Expiration Date: June 10, 2025

Agency Website



Amount Description

Direct costs are limited to $2 million in any one year.

The total project period may not exceed 5 years. The total length of support for any Center is limited to a maximum of ten years. 

Funding Type





Medical - Basic Science
Medical - Translational

External Deadline

June 7, 2023