Silvio O. Conte Digestive Diseases Research Core Centers (P30 Clinical Trial Optional)

Funding Agency:
National Institutes of Health

This Funding Opportunity Announcement (FOA) invites applications for Silvio O. Conte Digestive Diseases Research Core Centers (DDRCCs). The DDRCCs are part of an integrated program of digestive and liver diseases research support provided by the NIDDK.  The purpose of this Centers program is to bring together basic and clinical investigators as a means to enhance communication, collaboration, and effectiveness of ongoing research related to digestive and/or liver diseases.  DDRCCs are based on the core concept, whereby shared resources aimed at fostering productivity, synergy, and new research ideas among the funded investigators are supported in a cost-effective manner.  Each proposed DDRCC must be organized around a central theme that reflects the focus of the digestive or liver diseases research of the Center members. The central theme must be within the primary mission of NIDDK, and not thematic areas for which other NIH Institutes or Centers are considered the primary source of NIH funding.  

Only one application per institution is allowed.


  • Duke Internal Deadline: Mar. 6, 2020
  • Letter of Intent Due Date: 30 days prior to the application due date
  • Application Due Date(s): November 1, 2019 and July 1, 2021

RFA-DK-19-004 Expiration Date July 2, 2021

Agency Website

Eligibility Requirements

Only institutions at which there is a strong ongoing base of digestive and/or liver diseases-relevant research that relates to the proposed theme of the Center are eligible. The already funded research base must have at least $3 million per year in direct costs of supported research within a proposed theme area that is of primary interest to NIDDK.  These may be a mix of Federal and privately funded research awards or research career development awards. However, at least 30 percent of the total funding contributing to the research base must be secured from the NIDDK. Moreover, enough awards within the research base must be Federal to fulfill the requirement that each Biomedical Research Core must be utilized by a minimum of two federally funded Center members. Training grants, education grants, and fellowship awards are not considered part of the research base funding.  Since "Facilities and Administration" costs vary considerably between institutions, these must not be included in the calculation of the research base.



Amount Description

Application budgets are limited to $750,000 in direct costs per year and need to reflect the actual needs of the proposed Center.

The project period for an application submitted to this funding opportunity may not exceed five years.   

      Funding Type





      Medical - Basic Science
      Medical - Clinical Science

      Internal Nomination

      Owing to the sponsor's restriction on the number of applications that may be submitted from Duke, anyone wishing to pursue nomination should submit the following materials as one PDF.

      • NIH biosketch of project leader
      • 1-2 page document (LOI) containing:
        • Descriptive title of proposed activity
        • Name(s), address(es), and telephone number(s) of the PD(s)/PI(s)
        • Names of other key personnel
        • Participating institution(s)
      • Project summary (30 lines of text)

      Project narrative (3 sentences

      Please submit internal materials through My Research Proposal. (Code ILN)

      Instructions for both creating an account (if you don't already have one) and submitting your materials can be found here:

      Internal Deadline

      March 6, 2020

      External Deadline

      July 1, 2021