Single-Cell Analysis of Inflammation

Funding Agency:
Chan Zuckerberg Initiative

Inflammation is a feature of many diseases and a cross-cutting area of biomedicine. Inflammation mediates the response to chronic and acute tissue injury and infection, driving homeostasis and tissue repair. It is also a driver of fibrosis, cardiovascular disease, inflammatory bowel disease, arthritis, neurodegeneration, adverse events associated with immunotherapies, and many other maladaptive processes. Mapping inflammation in diverse tissues is a path to understanding, diagnosing, and potentially treating many different diseases.

CZI seeks applications aimed toward identifying unifying principles that underlie tissue homeostasis and inflammation at the single cell level. Our goal is to stimulate collaborations across disciplines that will help define a new field. Successful applications will bring together researchers in different experimental, computational, or medical domains. They will address local cell properties and interactions in inflamed tissues and compare them to the properties and interactions of similar cells in healthy tissues. They will increase our understanding of the cell types that mediate inflammation, and their interactions in space and time. The two-year pilot grant period is intended to develop proof-of-concept for the experimental team and the approach, setting up future programs for detailed mechanistic investigations.

This program is aimed toward developing new teams, consisting of two or three principal investigators with different areas of expertise, who can advance interdisciplinary analysis of inflammation.

Deadline: Nov. 19, 2019

Agency Website

Eligibility Requirements

● Applicants must hold a PhD, MD, or equivalent degree. ● Applicants must have an academic appointment and be in an independent faculty position or equivalent at an accredited college, university, medical school, or other research facility. Independence is typically demonstrated by a full-time faculty appointment, a tenure-track position, allocated space, a start-up package, and institutional commitment as defined or verified in a letter from a department chair or equivalent.● Applications may be submitted by domestic and foreign non-profit organizations; public and private institutions, such as colleges, universities, hospitals, laboratories, units of state and local government; and eligible agencies of the federal government. ● Collaborations should include two or three principal investigators (PIs). ● Collaborations should be interdisciplinary. ● Each PI may only participate in one application. 

Amount Description

The grant budget will be $175K in total costs per participating Principal Investigator over the duration of the two-year project (including no more than 15% indirect costs). ● If there are two Principal Investigators, the total grant budget will be $350K. ● If there are three Principal Investigators, the total grant budget will be $525K. The preliminary budget should detail the support requested for each Principal Investigator. While unequal distribution of funds among PIs is allowed, it should be justified in the application.

Funding Type





Engineering and Physical Sciences
Environmental & Life Sciences
Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

November 19, 2019