Sponsor Deadline
Posted: 4/6/2025

Small Business Transition Grant for New Entrepreneurs (R41/R42, R43/R44 Clinical Trial Not Allowed)

Through this Notice of Funding Opportunity (NOFO), the National Institutes of Health (NIH) and Centers for Disease Control and Prevention (CDC) aim to foster the advancement and accelerate the growth of early-career scientists transitioning to entrepreneurship by simultaneously supporting their entrepreneurial development and the conduct of research and development under their direction.

This NOFO supports small business concerns (SBCs) in employing and developing researchers as entrepreneurial Program Directors/Principal Investigators (PDs/PIs). In addition to supporting research and development efforts at the SBC, a major component of this NOFO is entrepreneurial training, mentoring, and career development of the PD/PI. Optimal PDs/PIs for this award are scientists and professionals with research, technology development, and/or healthcare delivery skills and experience, but limited entrepreneurial and independent (non-mentored) research leadership experience. PDs/PIs are expected to grow their entrepreneurial skillset while working in a small business to develop promising technologies and products that align with NIH's or CDC’s missions to improve health and save lives.

This NOFO invites eligible United States small business concerns (SBCs) to submit SBIR Phase I and Fast-Track grant applications. Small business applicants interested in submitting an STTR grant application should submit to PAR-24-133. Applications submitted to this NOFO are not allowed to propose clinical trial(s). SBIR applications that propose clinical trial(s) should be submitted to PAR-24-132. Direct to Phase II applications are not allowed under this funding opportunity and should be submitted to another SBIR Notice of Funding Opportunity.

Deadlines:

  • Letter of Intent Due Date(s): 30 days prior to the application due date
  • Application Due Dates: Sep. 5, Jan. 5, Apr. 5

PAR-24-131 Expiration Date April 06, 2027

Eligibility Requirements

Only United States small business concerns (SBCs) are eligible to submit applications for this opportunity. 

This NOFO supports the transition of early-career researchers into entrepreneurial roles, and eligibility of the contact PD/PI is limited to scientists, engineers, and health professionals, including certain late-stage students, postdoctoral fellows or associates, clinicians, and public health practitioners, who are new to research entrepreneurship and have not independently led significant research programs. (See Section III for eligibility information.) The transitioning researcher should possess research skills and experience in scientific discovery or technology development. All eligible scientists are encouraged to apply; optimal PDs/PIs for this award may be Early Stage Investigators or New Investigators. NIH always encourages individuals from diverse backgrounds, including individuals from underrepresented groups in the biomedical, clinical, behavioral, and social sciences, such as individuals from underrepresented racial and ethnic groups, individuals with disabilities, individuals from other disadvantaged backgrounds, and women to work with their organizations to apply for NIH support. (See Notice of NIH's Interest in Diversity, NOT-OD-20-031; see also Reminder: Notice of NIH's Encouragement of Applications Supporting Individuals from Underrepresented Ethnic and Racial Groups as well as Individuals with Disabilities, NOT-OD-22-019.)