Somatic Mosaicism across Human Tissues (SMaHT) Program: Data Analysis Center (UM1 Clinical Trial Not Allowed)

Funding Agency:
National Institutes of Health

This Funding Opportunity Announcement (FOA) invites applications to establish the Data Analysis Center (DAC) for the Somatic Mosaicism across Human Tissues (SMaHT) Network.  The purpose of the SMaHT Network is to enable discovery of new biology and disease mechanisms mediated by genomic variation in somatic tissues. The Data Analysis Center will be responsible for the following areas: 1. Managing all data on behalf of the Network, including ingestion, uniform processing, and standardized annotation, and archiving of data; 2. Developing new computational methods and bioinformatics tools and deploying them as part of an accessible data workbench; 3. Building a data portal for the Network, including the SMaHT Variant Catalog and variant browser, and 4. Harmonizing SMaHT resources with related programs.

Companion FOAs:

RFA-RM-22-009 , U24 Resource-Related Research Project (Cooperative Agreements)
RFA-RM-22-011 , UG3UH3 Phase 1 Exploratory/Developmental Cooperative Agreement/Exploratory/Developmental Cooperative Agreement Phase II
RFA-RM-22-012 , U24 Resource-Related Research Project (Cooperative Agreements)
RFA-RM-22-013 , UM1 Research Project with Complex Structure Cooperative Agreement


  • Letter of Intent Due Date(s): June 08, 2022

  • Application Due Date: July 8, 2022

RFA-RM-22-010 Expiration Date July 09, 2022




Medical - Basic Science
Medical - Clinical Science

External Deadline

July 8, 2022