Somatic Mosaicism across Human Tissues (SMaHT) Program: Genome Characterization Centers (UM1 Clinical Trial Not Allowed)

Funding Agency:
National Institutes of Health

This funding opportunity announcement invites applications to establish the Genome Characterization Centers (GCCs) for the Somatic Mosaicism across Human Tissues (SMaHT) Network.  The purpose of the SMaHT Network is to enable discovery of new biology and disease mechanisms mediated by genomic variation in somatic tissues. The GCCs will be responsible for generating state of the art, high throughput genomic data characterizing somatic variants in a set of 10-15 human tissues from 150+ donors. The GCCs will work closely with the SMaHT Data Analysis Center to build the framework for a comprehensive catalog of variants.

Companion FOAs:

RFA-RM-22-009 , U24 Resource-Related Research Project (Cooperative Agreements)
RFA-RM-22-010 , UM1 Research Project with Complex Structure Cooperative Agreement
RFA-RM-22-011 , UG3/ UH3 Phase 1 Exploratory/Developmental Cooperative Agreement/Exploratory/Developmental Cooperative Agreement Phase II
RFA-RM-22-012 , U24 Resource-Related Research Project (Cooperative Agreements)


  • Letter of Intent Due Date(s): June 08, 2022

  • Application Due Date: July 8, 2022

RFA-RM-22-013 Expiration Date July 09, 2022




Medical - Basic Science
Medical - Clinical Science

External Deadline

July 8, 2022