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Stand Up To Cancer – Lustgarten Foundation Pancreatic Cancer Interception Dream Team
Submissions of ideas will be invited for a translational cancer research project that addresses critical problems in pancreatic cancer and positively impacts patients in the near future, with the goal of advancing innovative approaches to prevent or intercept the disease-causing process, and making data available in a format amenable to open access analytics. Prioritized areas of interest include both applied and fundamental research including: The discovery and implementation of innovative methods that effectively detects pancreatic cancer at an early and surgically curable stage; new tools for monitoring disease progression and therapeutic response, which could potentially serve as surrogate endpoints for clinical trials and regulatory approval; investigation of novel chemoprevention or immune prevention approaches; the development of risk prognostication methods for pre-invasive pancreatic neoplasms and other conditions that elucidates the molecular details underlying that increased risk; the understanding of immune suppression and inflammation mechanisms that promote pancreatic cancer and the design of methods to circumvent this; and more generally research targeted at generating sufficient knowledge to justify a clinical intervention to test novel hypotheses related to early detection and treatment of pancreatic cancer.
This proposed project is expected to benefit patients through investigation by a multidisciplinary, multi-institutional, synergistic Dream Team of expert investigators. Priority will be given to applications that are characterized by a diversity of team members, including those from fields outside the traditional realms of biomedical research (e.g. physics, mathematics, engineering, health policy, and communications). Specific aims of the project may include basic research, translational studies, and population studies but the overall proposal must have a strong clinical research component. Proposals for this Dream Team research project must present plans indicating how the work will be translated into clinical application. The concepts will be evaluated on innovation, feasibility, opportunities for success and further development, including improved long-term outcomes for patients.
Through a partnership with leading health care research and innovation collaborative OptumLabs, each team will have the ability to conduct research using OptumLabs' proprietary database of de-identified claims and electronic health record data, analytic tools, and research support to pursue the proposed goals of the Dream Team. Appendix A provides more information on OptumLabs. Collaboration with OptumLabs is optional, and anticipated participation should be delineated as part of the research proposal narrative.
- Letter of Intent: Mar. 22, 2017
- Invited Application: Jun. 26, 2017
To maximize creativity, innovation, and collaboration, the Dream Team must include laboratory and clinical researchers, senior and/or young investigators, and senior scientists who have not worked together in the past.
Each Team will consist of a Dream Team Leader, a Dream Team Co-leader, no more than four additional Dream Team Principals, and at least two Advocates.
The Dream Team Leader, Co-leader and Principals, collectively referred to as Key Personnel, must have acquired a doctoral or medical degree, and must be independent investigators affiliated with an academic, medical, or research institution. There are no citizenship or residency status restrictions.
The Dream Team Leader and Co-leader are expected to each dedicate at least 20 percent (or 40 percent combined) of their time and effort to the Dream Team research project. Dream Team Principals must each dedicate at least 10 percent of their time and effort to the Dream Team research project.
No Dream Team will have more than one Key Personnel (Dream Team Leader, Co-leader, or Principal) from any given institution at the time of their initial appointment on the Team. No more than two Key Personnel may be from affiliated institutions. It is expected that additional Investigators from the Dream Team Leader's, Co-leader's or Principals' institutions may be involved in the Dream Team research project in some other capacity, and there is no limit to the number of Investigators from each of these institutions that may contribute to the Dream Team project.