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Strategies to Prevent Unsafe Opioid Prescribing in Primary Care among Patients with Acute or Chronic Non-Cancer Pain
PCORI seeks to fund studies that compare two or more alternatives to prevent unsafe prescribing in primary care among patients with acute or chronic non-cancer pain, while ensuring adequate or improved pain management.
Proposed studies must address clinical and healthcare delivery choices faced by patients, their caregivers, clinicians, or delivery systems. Proposed studies must compare two or more active interventions. PCORI strongly encourages research that uses active comparators, if feasible. But, given the rapidly changing policy and practice environment for opioid prescribing, a “usual care” arm may be justifiable. They must involve patient populations that represent the U.S. population, be large enough to provide precise estimates of hypothesized effectiveness differences, and support evaluation of potential differences in treatment effectiveness in patient subgroups.
For this solicitation, applicants are not required to demonstrate that patients and other stakeholders are already engaged as research team members at the time an application is submitted. However, applicants should outline how patients and other stakeholders will participate as partners in various phases of the proposed research, once awarded. Applicants should describe their plan to form a Study Advisory Committee (SAC) or other appropriate engagement body, to ensure that a broad spectrum of patients and other stakeholders advise and assist the research team with refining the study questions, outcomes, and protocols. These patients and other stakeholders must include national or regional organizations that represent—at a minimum—patients, caregivers, clinicians, policy makers, and other healthcare system stakeholders. Additional representation may be recommended in collaboration with PCORI, including individual patients with lived experience and other relevant stakeholders, such as scientific and methodological experts.
Deadline for Letter of Intent: Oct. 2, 2017
Applications may be submitted by any private-sector research organization, including any non-profit or for-profit organization, and any public-sector research organization, including any university or college hospital or healthcare system, laboratory or manufacturer, or unit of local, state, or federal government. The Internal Revenue Service must recognize all US applicant organizations. Nondomestic components of organizations based in the United States and foreign organizations may apply, as long as there is demonstrable benefit to the US healthcare system and U.S. efforts in the area of patient-centered research can be clearly shown. Organizations may submit multiple applications for funding. Individuals are not permitted to apply.