Stroke Preclinical Assessment Network (SPAN) to Support Translational Studies for Acute Cerebroprotection - Testing Laboratories (U01 Clinical Trial Not Allowed)

Funding Agency:
National Institutes of Health

The purpose of this funding opportunity announcement (FOA) is to invite applications for testing laboratories to take part in the NINDS Stroke Preclinical Assessment Network (SPAN).SPAN will facilitate the testing of up to 8 promising cerebroprotective drugs or interventions to be given prior to or at the time of reperfusion in experimental models of ischemic stroke (e.g., transient middle cerebral artery occlusion (tMCAO)). Awarded testing laboratories will compose the main infrastructure of the network and will be expected to work with the SPAN Coordinating Center and intervention contributors to facilitate the parallel testing of multiple cerebroprotective interventions in experimental models of ischemic stroke. If successful, this network will accelerate the identification of the most promising neuroprotective therapies for future pivotal clinical trials and span the gap between preclinical and clinical testing, in a cost-and time-effective fashion.

This FOA only solicits applications for SPAN testing laboratories. As such, applications should solely focus on the expertise and infrastructure that each prospective testing site can bring to SPAN. Separate FOAs are issued to solicit applications for specific cerebroprotective intervention research projects to be tested in SPAN (RFA-NS-22-032, RFA-NS-22-033) and for the Coordinating Center (RFA-NS-22-004).


  • Letter of Intent Due Date(s): 30 days prior to application due date.

  • Application Due Date: March 14, 2022

RFA-NS-22-003 Expiration Date March 15, 2022

Agency Website

Eligibility Requirements

It is preferable that only one PD/PI be identified on each testing laboratory application.

While applications from the same institution can be submitted to both the SPAN testing laboratory and intervention FOAs, an award would only be made for one or the other to avoid a conflict of interest (i.e., an institution can serve as either a testing laboratory or an intervention contributor, but not both). Likewise, the recipient of a CC U24 is ineligible for a second SPAN award under either the testing lab or interventions FOAs.

To diversify the network, only one testing laboratory award per institution is allowed. A testing laboratory application must be from a single institution, which may include geographically or organizationally linked partners or sites, though this is not required.

Amount Description

Application budgets are limited to $400,000 in direct costs per year for 3 years.

The maximum project period is 3 years.

Funding Type





Medical - Clinical Science
Medical - Translational

External Deadline

March 14, 2022