Stroke Preclinical Assessment Network (SPAN) to Support Translational Studies for Acute Neuroprotection - Coordinating Center (U24 Clinical Trial Not Allowed)

Funding Agency:
National Institutes of Health

Recent advances in endovascular thrombectomy offer a new opportunity to reconsider neuroprotective agents as adjunctive therapies to extend the time window for reperfusion and to improve long-term functional outcome. The purpose of this funding opportunity announcement (FOA) issued by NINDS is to invite applications for the Coordinating Center (CC) for the NIH Stroke Preclinical Assessment Network (SPAN). SPAN will facilitate testing of up to 6 promising neuroprotective drugs or interventions to be given prior to or at the time of reperfusion in experimental models of ischemic stroke (e.g., transient middle cerebral artery occlusion). The CC will work with the awarded network sites (RFA-NS-18-033) and will provide centralized administrative oversight and coordination of all aspects of the network. If successful, this network will accelerate the identification of the most promising neuroprotective therapies for future pivotal clinical trials and span the gap between preclinical and clinical testing, in a cost-and time-effective fashion.


  • Letter of Intent Due Date(s): November 13, 2018
  • Application Due Date(s): December 13, 2018

RFA-NS-18-034 Expiration Date December 14, 2018

Agency Website



Amount Description

Application budgets may not exceed $500,000 in direct costs per year but need to reflect the actual needs of the proposed project.

The maximum project period is 3 years.

Funding Type





Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

December 13, 2018