Stroke Preclinical Assessment Network (SPAN) to Support Translational Studies for Acute Neuroprotection (U01 Clinical Trial Not Allowed)

Funding Agency:
National Institutes of Health

Recent advances in endovascular thrombectomy and the extended time window for intervention in acute ischemic stroke patients that have salvageable brain tissue at the time of reperfusion, offer a new opportunity to reconsider neuroprotective agents as adjunctive therapies to extend the time window for reperfusion and to improve long-term functional outcome.

The purpose of this funding opportunity announcement (FOA) issued by NINDS is to invite applications for network sites for the NIH Stroke Preclinical Assessment Network (SPAN).  SPAN will facilitate testing of up to 6 promising neuroprotective drugs or interventions to be given prior to or at the time of reperfusion in experimental models of ischemic stroke (e.g., transient middle cerebral artery occlusion). The awarded network sites will become part of the network and will collaborate with the other awarded sites under the oversight and central coordination provided by the SPAN Coordinating Center (RFA-NS-18-034).  Applicants for the network sites must propose a promising neuroprotective intervention to be tested within SPAN; awarded sites will test up to 6 interventions in parallel, including their own. If successful, this network will accelerate the identification of the most promising neuroprotective therapies for future pivotal clinical trials and span the gap between preclinical and clinical testing, in a cost-and time-effective fashion.


  • Letter of Intent Due Date(s): November 13, 2018
  • Application Due Date(s): December 13, 2018

RFA-NS-18-033 Expiration Date December 14, 2018

Agency Website



Amount Description

Application budgets are limited to $725,000 in direct costs for 3 years ($75,000 direct cost during year 1 to set up the network, then $325,000 in direct costs per year).

Funding Type





Medical - Basic Science
Medical - Clinical Science
Medical - Translational

External Deadline

December 13, 2018