Sponsor Deadline
Posted: 3/18/2024

Sustained Support for Informatics Technologies for Cancer Research and Management (U24 Clinical Trial Optional)

The purpose of this Notice of Funding Opportunity  (NOFO) is to invite Cooperative Agreement (U24) applications for the continued development and sustainment of high value informatics research resources to improve the acquisition, management, analysis, and dissemination of data and knowledge across the cancer research continuum including cancer biology, cancer treatment and diagnosis, early cancer detection, risk assessment and prevention, cancer control and epidemiology, and/or cancer health disparities. As a component of the NCI's Informatics Technology for Cancer Research (ITCR) Program, this NOFO focuses on sustaining operations and improving the user experience and availability of existing, widely-adopted informatics tools and resources. This is in contrast to early-stage and advanced development efforts to generate these tools and resources that are supported by companion ITCR NOFOs. The central mission of ITCR is to promote research-driven informatics technology across the development lifecycle to address priority needs in cancer research. In order to be successful, the proposed sustainment plan must provide clear justification for why the research resource should be maintained and how it has benefited and will continue to benefit the cancer research field. In addition, mechanisms for assessing and maximizing the value of the resource to researchers and supporting collaboration and deep engagement between the resource and the targeted research community should be described.

ITCR provides support for informatics technology development through four NOFOs aimed at distinct phases of the technology development lifecycle:

  • RFA-CA-24-016 (R21, Clinical Trial Optional) Supports the development of highly innovative informatics methods and algorithms 
  • RFA-CA-24-017 (U01, Clinical Trial Optional) Supports initial tool development or the significant modification of existing tools for new applications
  • RFA-CA-24-018 (U24, Clinical Trial Optional) Supports the continued development of emerging informatics technology that has passed the initial prototyping and pilot development stage, has demonstrated potential to have a significant and broader impact, has compelling reasons for further improvement and enhancement
  • RFA-CA-24-019 (this NOFO, U24, Clinical Trial Optional) Supports sustaining operations and improving the user experience and availability of existing, widely-adopted informatics tools and resources


  • Letter of Intent Due Date: 30 days before the due date
  • Application Due Date(s): June 11, 2024; Nov. 15, 2024

RFA-CA-24-019 Expiration Date November 16, 2024