Systems Approach to Immunity and Inflammation (U19)

Funding Agency:
National Institutes of Health

The purpose of this Funding Opportunity Announcement (FOA) is to develop a comprehensive understanding of innate and adaptive immune responses triggered by pathogens, adjuvants, or vaccines using a systems biology approach.  The basis of the research program will be to conduct forward genetic screens of mutant or genetically diverse mice, combined with systems level analysis, to identify previously unappreciated key immune regulatory genes, signaling pathways, or mechanisms; and will include validation of these pathways in human cells and tissues.  The long-range goal of this program is to advance our understanding of immune response dynamics following infection with a pathogen or administration of an adjuvant or vaccine; and to provide foundational information that can be applied to the development of novel translational approaches for production of vaccines or immune-based therapeutics.  


  • Letter of Intent Due Date(s): October 2, 2016
  • Application Due Date(s): November 2, 2016

​RFA-AI-16-050 Expiration Date November 3, 2016

Agency Website



Amount Description

The budget for each application cannot exceed $1,500,000 in direct costs per year, which includes $100,000 (minimum) to $200,000 (maximum) in direct costs per award, per year, for years 2-5 for the Pilot Project Program.   

The scope of the proposed project should determine the project period.  The maximum project period is five years.  

Funding Type





Medical - Basic Science
Medical - Clinical Science

External Deadline

November 2, 2016