Systems Biology of Bioenergy-Relevant Microbes to Enable Production of Next-Generation Biofuels and Bioproducts

Funding Agency:
Department of Energy

Biological and Environmental Research (BER) of the Office of Science (SC), U.S. Department of Energy (DOE), hereby announces its interest in receiving applications for research that supports the Genomic Science research program ( In this FOA, applications are requested for: i) research to advance the development of promising new model organisms relevant to Biofuels and/or Bioproducts production; and ii) research to develop an understanding of novel microbial functional capabilities and biosynthetic pathways relevant to the production of advanced Biofuels and Bioproducts. 

The DOE-BER Genomic Science program supports basic research aimed at identifying the foundational principles that drive biological systems. These principles govern the translation of the genetic code into integrated networks of proteins, enzymes, regulatory elements, and metabolite pools that are the functional processes of organisms including microbes and multispecies communities relevant to DOE missions in energy and the environment. To address the DOE mission in sustainable Bioenergy development, the Genomic Science program brings omics-driven tools of modern systems biology to bear on the challenges associated with microbial production of advanced Biofuels and Bioproducts.

Developing an increased understanding of how biological systems function and translating that knowledge to enhance the production capabilities of microbes and plants forms the basis of DOE’s mission in sustainable Bioenergy. To harness the biosynthetic processing power of the microbial world for advanced Biofuels and Bioproducts production, an expanded set of platform organisms with appropriate metabolic capabilities and stress tolerance characteristics with a suite of modification tools will need to be developed. To foster this development, the DOE-BER Genomic Science program supports research aimed at understanding the principles that govern the functional properties of bioenergy relevant organisms at the genomic scale. This endeavor is highly interdisciplinary, spanning multiple fields in biology, systems biology, chemical and metabolic engineering, and computational biology.

For this FOA, relevant biofuels are non-food crop-derived and/or microbiologically synthesized fuels other than ethanol, and bioproducts are those that will replace petroleum derived non-pharmaceutical chemicals.


  • Required Pre-application: Jan. 8, 2018
  • Application: Mar. 23, 2018

Agency Website

Amount Description

It is anticipated that up to $8 million will be available for multiple awards to be made in Fiscal Year 2018, with an additional $8 million available per year, up to three years, contingent on the availability of appropriated funds. The number of awards will be contingent on satisfactory peer review, the availability of appropriated funds, and the size of the awards. Multiple year funding is expected. Applications may request project support for up to three years, with future-year support contingent on the availability of funds, progress of the research, and programmatic needs. 

Ceiling: $500,000 per year

Floor: $250,000 per year

Funding Type





Engineering and Physical Sciences
Environmental & Life Sciences

External Deadline

January 8, 2018