Systems Biology: The Next Generation for Infectious Diseases (U19)

Funding Agency:
National Institutes of Health

This Funding Opportunity Announcement (FOA) solicits applications to establish Systems Biology Centers that use systems biology approaches to build predictive models for infectious diseases.  These models will be derived from hypotheses related to systems-level host/pathogen molecular interactions during infection or treatment using integrated datasets generated from a combination of high-throughput experimental approaches, including omics technologies and computational approaches. Importantly, the Centers must clearly integrate experimental approaches and computational modeling to test and validate hypotheses of significance to the infectious diseases field. 


  • Letter of Intent Due Date(s): February 15, 2017
  • Application Due Date(s): March 15, 2017

RFA-AI-16-080 Expiration Date March 16, 2017

Agency Website

Eligibility Requirements

The scope of this work requires that interdisciplinary teams be formed that are capable of pursuing coordinated activities that bridge disparate scientific disciplines and expertise in microbiology, immunology, infectious diseases, microbiome, HTP experimental and omics technologies, together with experts in mathematics, physics, bioinformatics, computational biology, machine learning and statistical methods and modeling. Bringing multidisciplinary groups together creates opportunities for synergy that would rarely happen otherwise. The research teams within each Center may be composed of investigators located at one institution, or may be formed through a consortium of different institutions.



Amount Description

Budgets for direct costs of up to $2,000,000 per year may be requested.

The scope of the proposed project should determine the project period.  The maximum project period is 5 years.

Funding Type





Engineering and Physical Sciences
Environmental & Life Sciences
Medical - Basic Science
Medical - Clinical Science
Social Sciences

External Deadline

March 15, 2017