Tobacco Regulatory Science (R01 Clinical Trial Optional)

Funding Agency:
National Institutes of Health

The purpose of this Notice of Funding Opportunity (NOFO) is to invite R01 applications to support biomedical and behavioral research that will provide scientific data to inform regulation of tobacco products to protect public health. Research Projects must address the research priorities related to the regulatory authority of the Food and Drug Administration (FDA) Center for Tobacco Products (CTP). The awards under this NOFO will be administered by NIH using funds that have been made available through FDA CTP and the Family Smoking Prevention and Tobacco Control Act (P.L. 111-31). Research results from this NOFO are expected to generate findings and data that are directly relevant in informing the FDA's regulation of the manufacture, distribution, and marketing of tobacco products to protect public health.


  • Letter of Intent Due Date(s): 60 days prior to the application due date. Please note, although LOIs are typically due 30 days before the due date, for this NOFO LOIs are due 60 days prior to the application date.

  • Application Due Dates: Oct 6, 2023; May 5, 2024; Oct 4, 2024; May 2, 2025

RFA-OD-23-017 Expiration Date May 05, 2025

Agency Website



Amount Description

Application budgets are limited to $500,000 in direct costs per year.

The scope of the proposed project should determine the project period. The maximum project period is 5 years.   

Funding Type





Medical - Basic Science
Medical - Clinical Science
Medical - Translational
Social Sciences

External Deadline

May 5, 2024