Towards Implementing Novel Training Methods to Enhance Cognition in Aging (U01 Clinical Trial Required)

Funding Agency:
National Institutes of Health

This RFA invites applications for planning awards to develop and finalize protocols for well-powered cognitive training intervention trials to remediate or prevent age-related cognitive decline as well as possibly prevent or delay the onset of mild cognitive impairment and dementia. Planning activities may include the collection of pilot data and the refinement of cognitive training protocols consistent with Stage I of theĀ NIH Stage Model. Trial designs must justify the means used to assess cognition and to explore the underlying mechanisms of change. Such methods as structural and functional neuroimaging with biomarkers justified by an underlying model of change, CSF fluids, and blood biomarkers are appropriate candidate tools.


  • Letter of Intent Due Date(s): March 30, 2018
  • Application Due Date(s): April 30, 2018

RFA-AG-18-031 Expiration Date May 1, 2018




Medical - Basic Science
Medical - Clinical Science
Medical - Translational
Social Sciences

External Deadline

April 30, 2018