Transformative Research on the Basic Mechanisms of Polysubstance use in Addiction (R01 - Clinical Trials Optional)

Funding Agency:
National Institutes of Health

This notice of funding opportunity (NOFO) will support projects proposing mechanistic studies that will transform our understanding of polysubstance use in addiction. These hypothesis-based, exploratory projects may investigate mechanisms of polysubstance use at the behavioral, cognitive, cellular, circuit, genetic, epigenetic, pharmacological and/or computational levels.

This NOFO requires a plan for enhancing diverse perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation. Applications that fail to include a PEDP will be considered incomplete and will be withdrawn. Applicants are strongly encouraged to read the NOFO instructions carefully and view the available PEDP guidance material.  


  • Letter of Intent Due Date(s): June 17, 2024
  • Application Due Date: July 17, 2024

RFA-DA-25-043 Expiration Date July 18, 2024

Agency Website

Amount Description

Application budgets will be limited to $350,000 in direct costs/year. The proposed budget needs to reflect the actual needs of the proposed project.

The scope of the proposed project should determine the project period. The maximum project period is five years.

    Funding Type





    Engineering and Physical Sciences
    Environmental & Life Sciences
    Medical - Basic Science
    Medical - Clinical Science
    Medical - Translational

    External Deadline

    July 17, 2024