The purpose of this Funding Opportunity Announcement (FOA) is to solicit U24 applications for the establishment of the Coordinating and Data Management Center (CDMC), one of the two units of the Translational and Basic Science Research in Early Lesions (TBEL) program. The TBEL program aims to integrate basic and translational cancer research studies to further understand the biological and pathophysiological mechanisms driving or restraining precancers and early cancers and facilitate biology-based precision prevention approaches. The responsibilities of the CDMC are to (1) coordinate program-wide meetings and conferences, and cross-network collaborative activities; (2) provide statistical and computational analysis support; and (3) serve as a program data hub for data capture, curation and management, and protocol development.

The other unit of TBEL will be the multidisciplinary U54 Research Centers supported by a companion FOA. The aim of the Research Centers is to integrate basic and translational cancer research studies to iteratively examine the direct causal relationships and interactions of an early lesion, its microenvironment, and host-systemic factors as “co-organizers” of tumor initiation (or suppression) and malignant progression in conjunction with the clinical characteristics of the lesions.

Deadlines:

• Letter of Intent Due Date(s): 30 days prior to the application due date

• Application Due Date(s): November 2, 2021

RFA-CA-21-055 Expiration Date November 3, 2021