Understanding and Targeting the Pathophysiology of Youth-onset Type 2 Diabetes – Biostatistics Research Center (U01 Clinical Trial Not Allowed)

Funding Agency:
National Institutes of Health

This FOA invites applications for a Biostatistics Research Center to participate in a clinical consortium to better understand youth-onset type 2 diabetes. A separate FOA (RFA-DK-21-002) invites Clinical Centers to recruit a cohort of early pubertal youth at risk for developing type 2 diabetes and study them through puberty. The ultimate goals of this consortium will be to 1) develop more precise prediction of which individuals are truly at risk for developing youth-onset T2D and identify determinants of progression from prediabetes to T2D so that, ultimately, targeted prevention approaches can be developed and tested; and 2) increase understanding of the physiologic drivers of youth-onset T2D to guide development of more effective strategies to achieve glycemic control and preserve beta cell function.


  • Letter of Intent Due Date(s): February 3, 2022

  • Application Due Date: March 3, 2022

RFA-DK-21-003 Expiration Date March 04, 2022

Agency Website



Amount Description

Application budgets need to reflect the actual needs of the proposed project and may not exceed $2.5 million in annual direct costs.

The scope of the proposed project should determine the project period. The maximum project period is 5 years.

Funding Type





Engineering and Physical Sciences
Environmental & Life Sciences
Medical - Basic Science
Medical - Clinical Science

External Deadline

March 3, 2022