This Notice of Funding Opportunity (NOFO) invites applications that propose interdisciplinary research projects that utilize disease relevant human cell-based in vitro and ex vivo models to characterize the effects of gene-environment (GxE) interactions on gene regulation and cellular functions, and to elucidate toxicant mediated molecular and cellular mechanisms in brain aging and Alzheimer's Disease (AD) and AD-Related Dementias (ADRD). The objective of this initiative is to stimulate research to gain mechanistic insights into GxE interactions in response to environmental toxicants using human cell-based models.
This NOFO, in conjunction with its two companion NOFOs: RFA-AG-24-022 and RFA-AG-24-023, aims to establish a “Precision Environmental Health in AD/ADRD Tri-consortium” and lay the foundation for a precision environmental health approach to AD/ADRD risk reduction and disease prevention.
Deadlines:
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Letter of Intent Due Date(s): September 22, 2023
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Application Due Date: October 23, 2023
RFA-AG-24-021 Expiration Date October 24, 2023
Application budgets need to reflect the actual needs of the proposed project and must be limited to $500,000 in direct costs per year.
The scope of the proposed project should determine the project period. The maximum project period is 5 years.