Using a Total Environment Framework (Built, Natural, Social Environments) to Assess Life-long Health Effects of Chemical Exposures

Funding Agency:
Environmental Protection Agency

Recent research has recognized that the relationship between chemical pollutants and health effects is not necessarily straightforward. Rather, each person’s response is the combined cumulative result of interactions among chemical and non-chemical stressors from the built, natural, and social environments, along with inherent characteristics, activities/behaviors, and policies/programs.  Communities and local public-health agencies need a better scientific understanding of these interactions and cumulative effects to better protect and promote environmental health and well-being.

The U.S. Environmental Protection Agency (EPA), through its Science to Achieve Results (STAR) program, seeks applications for research on how pollution affects human health in the context of the total environment – built, natural, and social environments interacting together with inherent characteristics and interactions. Proposed research should develop and test innovative models or impact assessment approaches to examine causal relationships of chemical pollutants and health effects with modifying interactions among the variables representing all of the major stressors and factors involved in a person’s life. Proposals that integrate a diverse field of disciplines (social science, economics, epidemiology, engineering, environmental science, biology, statistics, toxicology, chemistry, etc.) to address the complexity of the total environment research problem are highly recommended.

Deadline: Mar. 2, 2017

Agency Website

Eligibility Requirements

Public nonprofit institutions/organizations (includes public institutions of higher education and hospitals) and private nonprofit institutions/organizations (includes private institutions of higher education and hospitals) located in the U.S., state and local governments, Federally Recognized Indian Tribal Governments, and U.S. territories or possessions are eligible to apply. Special eligibility criteria apply to the early career award portion of this RFA. See full announcement for more details.



Amount Description

Estimated Number of Awards: 5 regular and 5 early-career awards
Anticipated Funding Amount: Approximately $7 million total for all awards
Potential Funding per Award: Up to a total of $800,000 for regular awards and $600,000 for early career awards, including direct and indirect costs, with a maximum duration of four years.
Cost-sharing is not required. Proposals with budgets exceeding the total award limits will not be considered.

Funding Type



Junior Faculty


Engineering and Physical Sciences
Environmental & Life Sciences
Medical - Basic Science
Medical - Clinical Science
Social Sciences

External Deadline

March 2, 2017