Sponsor Deadline
Posted: 5/7/2024

Utilizing Invasive Recording and Stimulating Opportunities in Humans to Advance Neural Circuitry Understanding of Mental Health Disorders (R01, R21 Clinical Trial Optional)

The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications to pursue invasive neural recording studies focused on mental health-relevant questions. Invasive neural recordings provide an unparalleled window into the human brain to explore the neural circuitry and neural dynamics underlying complex moods, emotions, cognitive functions, and behaviors with high spatial and temporal resolution. Additionally, the ability to stimulate, via the same electrodes, allows for direct causal tests by modulating network dynamics. This FOA aims to target a gap in the scientific knowledge of neural circuit function related to mental health disorders. Researchers should target specific questions suited to invasive recording modalities that have high translational potential. Development of new therapies is outside the scope of this FOA, though development of novel tools/methods to enable relevant mental health studies is encouraged.

This FOA uses the R01 grant mechanism, encouraging longer-term projects, whereas its companion R21 FOA, PAR-23-101, seeks grant applications encouraging shorter, higher-risk studies.


  • R01 Due Date(s): Feb 5, Jun 5, Oct 5
  • R21 Due Dates: Feb. 16, Jun. 16, Oct. 16

PAR-23-093 Expiration Date New Date January 8, 2025 (Original Date: September 08, 2024) per issuance of NOT-MH-24-261

Funding Type