Utilizing Invasive Recording and Stimulating Opportunities in Humans to Advance Neural Circuitry Understanding of Mental Health Disorders (R01, R21 Clinical Trial Optional)

Funding Agency:
National Institutes of Health

The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications to pursue invasive neural recording studies focused on mental health-relevant questions. Invasive neural recordings provide an unparalleled window into the human brain to explore the neural circuitry and neural dynamics underlying complex moods, emotions, cognitive functions, and behaviors with high spatial and temporal resolution. Additionally, the ability to stimulate, via the same electrodes, allows for direct causal tests by modulating network dynamics. This funding opportunity aims to target a gap in the scientific knowledge of neural circuit function related to mental health disorders. Researchers should target specific questions suited to invasive recording modalities that have high translational potential. Development of new technologies and therapies is outside the scope of this FOA.

This FOA uses the R01 grant mechanism, encouraging longer-term projects, whereas its companion funding opportunity RFA-MH-20-351 seeks R21 grant applications encouraging shorter, higher-risk applications.

Application Due Date(s): February 10, 2020; October 9, 2020; June 10, 2021

RFA-MH-20-350 Expiration Date June 11, 2021




Medical - Basic Science
Medical - Clinical Science

External Deadline

October 9, 2020